Carlberg M, Hardell L. Decreased Survival of Glioma Patients with Astrocytoma Grade IV (Glioblastoma Multiforme) Associated with Long-Term Use of Mobile and Cordless Phones. International Journal of Environmental Research and Public Health. 2014; 11(10):10790-10805.

  • We analysed survival of 1678 glioma patients in our 1997–2003 and 2007–2009 case-control studies. Use of wireless phones in the >20 years latency group (time since first use) was correlated to decreased survival for those diagnosed with astrocytoma grade IV .
  • “Due to the relationship with survival the classification of IARC is strengthened and RF-EMF should be regarded as human carcinogen requiring urgent revision of current exposure guidelines.”
  1. Hardell, M. Carlberg, Cell and cordless phone risk for glioma – Analysis of pooled case-control studies in Sweden, 1997-2003 and 2007-2009, Pathophysiology (2014), Available online 29 October 2014.
  • “Conclusion. We previously analysed the evidence on glioma associated with the use of wireless phones using the Hill criteria [20]. We concluded that glioma and also acoustic neuroma are caused by RF-EMF emissions from wireless phones, and thus regarded as carcinogenic, under Group 1 according to the IARC classification, indicating that current guidelines for exposure should be urgently revised. This pooled analysis gives further support to that conclusion regarding glioma.”

Hardell L, Carlberg M, Söderqvist F, Mild K.(2013). Case-control study of the association between malignant brain tumours diagnosed between 2007 and 2009 and mobile and cordless phone use.International Journal of Oncology 43(6), 1833-45.

  • For persons with more than 25 years latency period (time since first use until tumour diagnosis) a 3-fold increased risk was found. The risk increased further for tumours located in the most exposed area of the brain, the temporal lobe, to a 5-fold increased risk.
  • “This study confirmed previous results of an association between mobile and cordless phone use and malignant brain tumours. These findings provide support for the hypothesis that RF-EMFs play a role both in the initiation and promotion stages of carcinogenesis”.

Hardell L, Carlberg M, Hansson, Mild K. (2006). Pooled analysis of two case-control studies on the use of cellular and cordless telephones and the risk of benign brain tumours diagnosed during 1997-2003. International Journal of Oncology. 509-18.

  • In the multivariate analysis, a significantly increased risk of acoustic neuroma was found with the use of analogue phones.

Hardell L, Carlberg M, Söderqvist F, Mild KH.(2013). Pooled analysis of case-control studies on acoustic neuroma diagnosed 1997-2003 and 2007-2009 and use of mobile and cordless phones. Int J Oncol. 43(4), 1036-44.

  • “Ipsilateral use resulted in a higher risk than contralateral for both mobile and cordless phones. OR increased per 100 h cumulative use and per year of latency for mobile phones and cordless phones, though the increase was not statistically significant for cordless phones. The percentage tumour volume increased per year of latency and per 100 h of cumulative use, statistically significant for analogue phones. This study confirmed previous results demonstrating an association between mobile and cordless phone use and acoustic neuroma.”

Hardell L, Carlberg M, Hansson Mild K. (2011). Pooled analysis of case-control studies on malignant brain tumours and the use of mobile and cordless phones including living and deceased subjects. Int J Oncol. 38(5):1465-74.

  • An increased risk was found for glioma and use of mobile or cordless phone. The risk increased with latency time and cumulative use in hours and was highest in subjects with first use before the age of 20.

Hardell L, Carlberg M. (2013). Using the Hill viewpoints from 1965 for evaluating strengths of evidence of the risk for brain tumors associated with use of mobile and cordless phones. Rev Environ Health. 28(2-3), 97-106.

  • “All nine issues on causation according to Hill were evaluated. The criteria on strength, consistency, specificity, temporality, and biologic gradient for evidence of increased risk for glioma and acoustic neuroma were fulfilled.
  • Based on the Hill criteria, glioma and acoustic neuroma should be considered to be caused by RF-EMF emissions from wireless phones and regarded as carcinogenic to humans, classifying it as group 1 according to the IARC classification. Current guidelines for exposure need to be urgently revised.”

Hardell L, Carlberg M, Hansson Mild K. (2013). Use of mobile phones and cordless phones is associated with increased risk for glioma and acoustic neuroma. Pathophysiology. 20(2):85-110.

  • “We give an overview of current epidemiological evidence for an increased risk for brain tumours including a meta-analysis of the Hardell group and Interphone results for mobile phone use. ..It is concluded that one should be careful using incidence data to dismiss results in analytical epidemiology. The IARC carcinogenic classification does not seem to have had any significant impact on governments’ perceptions of their responsibilities to protect public health from this widespread source of radiation”.

Carlberg M, Hardell L. Decreased Survival of Glioma Patients with Astrocytoma Grade IV (Glioblastoma Multiforme) Associated with Long-Term Use of Mobile and Cordless Phones. International Journal of Environmental Research and Public Health. 2014; 11(10):10790-10805.

  • Survival was analyzed for 1678 glioma patients in Hardells1997–2003 and 2007–2009 case-control studies. “Elevated HR (decreased survival) for the most malignant glioma type, astrocytoma grade IV, was found for long-term use of mobile and cordless phones.Highest HR was found for cases with first use before the age of 20 years. These results indicate a survival disadvantage for use of wireless phones in that patient group”.
  • “The study strengthens the proposed causal association between use of mobile and cordless phones and glioma. Due to the relationship with survival the classification of IARC is strengthened and RF-EMF should be regarded as human carcinogen requiring urgent revision of current exposure guidelines”.

 

Source:  http://ehtrust.org/science/read-the-research/

Cancer Studies by Hardell et al

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